Throughout his career, Anderszewski has concentrated on the classic German/Viennese repertoire encompassing Bach, Mozart, Beethoven, Schumann and Webern. He is also drawn to 20th century central European music, particularly that of Szymanowski and Janáček.

An exclusive artist with Warner Classics since 2000 - his first recording for the label was Beethoven's Diabelli Variations, which went on to receive a number of notable awards. He has recorded Grammy-nominated discs of Bach's Partitas 1, 3 and 6 and Szymanowski's solo piano works, the latter also receiving a Gramophone award in 2006. His recording devoted to works by Robert Schumann was named the BBC Music Magazine's Recording of the Year in 2012. Other Gramophone awards followed in 2015 for Bach English Suites and in 2021 for his specially selected set of 12 Preludes and Fugues from Bach’s Well Tempered Clavier Book 2. A live performance of the Preludes and Fugues from Hamburg’s Elbphilharmonie has since been released on DVD.

He has also recorded Mozart piano concertos with the Chamber Orchestra of Europe, the Scottish Chamber Orchestra and the Sinfonia Varsovia, as well as Beethoven's first piano concerto with the Deutsche Kammerphilharmonie Bremen.

His latest album is dedicated to piano works by Janáček, Szymanowski and Bartók.

Anderszewski has collaborated with various instrumentalists, including Viktoria Mullova, Frank Peter Zimmermann, Nikolaj Znaider and the Belcea Quartet. As a lieder partner, he has worked with Matthias Goerne and most recently in recital with Ian Bostridge featuring Schumann’s Dichterliebe.

Awarded the prestigious Gilmore Artist Award in 2002, Anderszewki’s artistic life has been the subject of several documentaries by the film maker Bruno Monsaingeon. 'Piotr Anderszewski plays Diabelli Variations' (2001) explores Anderszewski's particular relationship with Beethoven's iconic work. 'Unquiet Traveller' (2008) is an unusual artist portrait, capturing Anderszewski's reflections on music, the composers with whom he has a particular affinity and his Polish-Hungarian roots. In 2016 he found himself behind the camera directing "Warsaw is my name", a film dedicated to the city of his birth.

His appearances in the 25/26 season include solo recitals at Wigmore Hall, Philharmonie de Paris, Muziekgebouw, Amsterdam, Tonhalle Zurich, Ascona, Chopin and his Europe and Edinburgh International Festivals. He will also tour China, Japan and across Australia. His next recording of Brahms late piano works is due to be released in January 2026.

He is currently writing a book reflecting on his experience as a musician and performer.